THIS IS PART 1 OF A 2 PART SCHEMATIC! Part 2 is available here:
https://createmod.com/schematics/functional-square-factory-layer-2-vanilla-materials-only
Links to .schem files, .litematica files, and world download in the included YouTube video!

ADDITION: More modular rooms are available on the YouTube video. Layer 1 with a single 14 high block room and two layer 2 units stacked on top of each other for a single 14 high block room. Make your factory truly modular with those additional schematics!
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Create version and Minecraft version are irrelevant for this schematic! Materials are vanilla-only and available in 1.16.5+

This factory focuses on three key principles:

1. Flat, empty space to put all your machines and build freely (plus space inside the walls to hide your wiring!)


2. Materials that are easily acquired and/or automatable in most modpacks (Vanilla materials only!)


3. A design that is modular and can be layered infinitely upward (separate schematic for first layer and upward layers)

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Factory Statistics:

entire building dimensions: 53 blocks by 53 blocks
room/floor dimensions: 35 blocks by 35 blocks
ceiling height per floor: 8 blocks
between-walls width: average 3 blocks, sometimes 4
chunks needed for chunkloading purposes: 9 chunks (if positioned smart)

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TO USE SCHEMATIC:

Use "factory_layer1" schematic and paste it on the ground. The roof for the first schematic will be the floor for the second schematic. Once you want to add new floors, paste "factory_layer2" on top of your factory, making the roof of your factory the floor of your newly pasted schematic. I recommend observing the schematics in creative mode to understand better. Ladders will be pasted with schematic and you can make this factory as tall as you want. 

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Material Lists

Layer 1 Schematic:
Polished Andesite: 7643 (119 x 64 + 27) Stone Bricks: 3821 (59 x 64 + 45) Stone Brick Stairs: 750 (11 x 64 + 46) Polished Andesite Stairs: 626 (9 x 64 + 50) Stone: 419 (6 x 64 + 35) Torches: 368 (5 x 64 + 48) Dirt: 364 (5 x 64 + 44) Stripped Spruce Logs: 336 (5 x 64 + 16) Grass Block: 251 (3 x 64 + 59) Stone Brick Wall: 250 (3 x 64 + 58) Chiseled Stone Bricks: 164 (2 x 64 + 36) Polished Andesite Slab: 137 (2 x 64 + 9) Spruce Fence: 136 (2 x 64 + 8) Oak Leaves: 117 (1 x 64 + 53) Spruce Planks: 112 (1 x 64 + 48) Lantern: 88 (1 x 64 + 24) Ladder: 68 (1 x 64 + 4) Stone Slab: 19 Spruce Door: 6

Layer 2 Schematic:
Polished Andesite: 3162 (49 x 64 + 26) Stone Bricks: 1764 (27 x 64 + 36) Stone Brick Stairs: 416 (6 x 64 + 32) Stripped Spruce Logs: 336 (5 x 64 + 16) Torches: 203 (3 x 64 + 11) Polished Andesite Stairs: 188 (2 x 64 + 60) Spruce Fence: 136 (2 x 64 + 8) Chiseled Stone Bricks: 112 (1 x 64 + 48) Spruce Planks: 112 (1 x 64 + 48) Polished Andesite Slab: 64 Stone Brick Wall: 60 Lantern: 36 Ladder 32 Spruce Door: 2

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CREDIT:

Original wall design inspired from Madeline's Rats on Pinterest. Link below:
https://www.pinterest.com/pin/81135230781226175/